EIF4G1 and infection: Infection by enteroviruses induces a profound shut-off of cellular translation caused by the cleavage of eIF4G by a viral protease into an N-terminal fragment that binds eIF4E and PABP and a C-terminal fragment that binds eIF4A and eIF3, and by the dephosphorylation and consequent activation of the translation repressor 4E-BP.