During the viral infection phase, the virus expresses various immune-modulatory proteins, such as interleukin-10 homolog (ORFV127), chemokine binding protein (CBP), granulocyte–macrophage colony-stimulating factor inhibitory protein (GIF), immunomodulators of the nuclear factor kappa (NF-κB) signaling pathway (e.g., ORFV121), and vascular endothelial growth factor (VEGF). This evidence concerns the gene VEGFA and viral infectious disease.