IL4 and Herpesviridae infectious disease: This pattern of cytokine kinetics differs from that seen with traditional Th1-dominant vaccines, such as those adjuvanted with CpG, where a surge in IFN-γ typically suppresses Th2-associated cytokines like IL-4 and IL-6 [28].The Th1/Th2 co-activation, which we observed, aligns with emerging strategies for combating complex herpesvirus infections [29].