NOS3 and hypertensive disorder: Indicative therapy occurred for hypertension, hypotension, and thrombocytes’ function (without affecting the coagulation cascade) [11,29,97,98,99,187,188] and signaling pathways controlling vasomotor tone [92,93,94] (VEGFR2-Akt-eNOS and Src-Caveolin-1-eNOS).