A key factor appears to be the number of tumor-infiltrating lymphocytes (TILs) expressing programmed cell death type 1 (PD-1), lymphocyte activation gene 3 (LAG3), T-cell immunoreceptor with Ig and ITIM domains (TIGIT), and T-cell immunoglobulin and mucin domain 3 (TIM3) markers. This evidence concerns the gene LAG3 and neoplasm.