PARP1 and colorectal carcinoma: Also, bivariate correlation demonstrated indirect correlations between the PARP genes and their promoter methylation in the TCGA cohort (methylation data were not available for the Sidra-LUMC cohort), while one-way ANOVA showed that PARP1 and PARP2 copy number alterations (CNAs) were correlated with PARP1 and PARP2 expression, respectively, in both CRC cohorts (Supplementary Materials S4).