Notably, in a metabolic-dysfunction-associated steatohepatitis (MASH)-induced mouse model of liver fibrosis, the activation of the NF-κB signaling pathway and elevated angiopoietin-2 expression are found to precipitate pathological angiogenesis and LSEC defenestration [48]. The gene discussed is ANGPT2; the disease is metabolic dysfunction-associated steatohepatitis.