IL10 and depressive symptom measurement: However, in another study with sertraline, IL-10 decreased (unipolar depression) [204], and another study on patients with MDD given escitalopram showed no significant effect on IL-10 serum levels [198] and a non-statistically significant increase with sertraline (one study, hemodialysis patients with depression) [216] (Table 1 and Figure 2).