In our review, we noticed that CRP decreased with the administration of the SSRI sertraline (one study, congestive heart failure and depression [217]), the SNRI venlafaxine (one study, patients with MDD [220]), ketamine (one study, patients with post-operative cognitive dysfunction after cardiac surgery [251]), and esketamine (one study, labor and postpartum depression [218]). The gene discussed is CRP; the disease is depressive disorder.