In our review, we noticed that IL-10 decreased with the administration of the SSRI escitalopram (one study, moderate depression) [191] and ketamine (one study, treatment-resistant depression) [195], and it increased with the SSRI fluoxetine (one study, Crohn’s disease) [231], paroxetine (one study, MDD) [220], and esketamine (one study, labor and postpartum depression) [218]. This evidence concerns the gene IL10 and Crohn disease.