In melanoma, the primary driver mutations occur in v-raf murine sarcoma viral oncogene homolog B (BRAF (40–50%) and neuroblastoma RAS viral oncogene homolog (NRAS) (15–30%) [18,19], which are key components of the mitogen-activated protein kinase (MAPK) cascade and are associated with increased glucose uptake and fuel aerobic glycolysis [20,21]. The gene discussed is BRAF; the disease is melanoma.