For example, the silencing of SAMMSON, an SOX10-regulated lncRNA present in more than 90% of melanomas, not only impairs mitochondrial homeostasis by inducing apoptosis but also potentiates the efficacy of BRAF and MEK inhibitors by hindering the ability of cells to adapt metabolically to the MAPK pathway blockade [110]. The gene discussed is BRAF; the disease is melanoma.