HIF1A and melanoma: Similarly, the LINC00518 and CCHE1 lncRNAs boost the glycolysis: firstly, acting as a sponge for miR-33a-3p, they reduce its inhibition on HIF-1α, enhancing the HIF-1α/LDHA axis by increasing tumor radioresistance [105]; in the latter case, CCHE1-driven metabolic reprogramming supports the FGFR1-LDHA complex to increase glycolysis, which in turn promotes melanoma progression and chemoresistance [106].