JAK2 and central nervous system cancer: Then, other thiosemicarbazone derivatives can act through the induction of apoptosis; for example, the compound di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT) with a thiosemicarbazone moiety induces apoptosis through the downregulation of Interleukin-6 (IL-6) and Janus Kinase 2/Signal Transducer and Activator of Transcription 3 (JAK2/STAT3) pathway in glioma [35].