LRRK2 and Parkinson disease: In dopaminergic neurons, hyperactivation of Nicotinamide Adenine Dinucleotide Phosphate (NADPH) oxidase isoform 2 (NOX2) and leucine-rich repeat kinase 2 (LRRK2) has been related to the pathogenesis of PD, while neuroprotection is observed upon Nrf2 activation.