Some preclinical studies revealed that statins induce autophagy through AMPK/mTOR pathway activation, enhancing the clearance of Aβ and tau aggregates in AD models (e.g., simvastatin reduced neuroinflammation and oxidative stress in ischemic stroke models by upregulating pAMPK/LC3B/LAMP2 signaling, promoting autophagolysosome-mediated mitophagy) [78]. Here, MAPT is linked to Alzheimer disease.