Repeated mutations that occur at the onset of pathogenesis lead to the accumulation of growth factors that promote aberrant cell and tumor proliferation, such as vascular endothelial growth factor (VEGF), epidermal growth factor (EGF), platelet-derived growth factor (PDGF), hepatocyte growth factor (HGF) and the loss of phosphoenzyme analog (PTEN) [3]. This evidence concerns the gene EGF and neoplasm.