Elevated levels of APOB and reduced levels of APOA-I are among the most significant indicators for predicting intracranial atherosclerotic stenosis (ICAS) [55,176] since APOB and APOA-I serve as the core components of low-density lipoprotein (LDL) and HDL, respectively. The gene discussed is APOA1; the disease is familial isolated congenital asplenia.