Induced by iron overload, antioxidant deficiency, or drugs targeting GPX4 or system Xc−, and inhibited by iron chelators, antioxidants, or GPX4 overexpression, ferroptosis participates in multiple pathological processes, including cancer, neurodegenerative diseases, and IRI, making its characteristic mechanisms potential therapeutic targets [13]. The gene discussed is GPX4; the disease is neurodegenerative disease.