IKBKB and cystic fibrosis: For example, pro-inflammatory cytokines IL-6 and IL-8 are overproduced, the first from CF macrophages upon LPS stimulation in response to high levels of miR-146a [135], and the second as a consequence of miR-17 and miR-93 deregulation in bronchial epithelial cells infected by P. aeruginosa [136,137] and, again, of miR-199a-3p, which also increases IKKβ expression that, in turn, hyperactivates the NF-κB pathway in CF airway epithelial cells [133].