The four proteins targeted in this study, namely the NR1 ligand-binding core, Human Beta Secretase (BACE1), Human Monoamine Oxidase-A (MAO-A), and Recombinant Human Acetylcholinesterase (AChE), play crucial roles in the complex and interconnected pathogenesis of AD. The gene discussed is BACE1; the disease is Alzheimer disease.