TNFRSF11B and postmenopausal osteoporosis: Unlike aging, where reduced bone formation and microdamage accumulation lead to progressive trabecular number and size reduction [42,43], postmenopausal osteoporosis, driven by estrogenic deficiency, induces RANKL and decreases OPG, causing increased resorption with selective horizontal trabecular loss and vertical trabecular thickening [44].