Unlike aging, where reduced bone formation and microdamage accumulation lead to progressive trabecular number and size reduction [42,43], postmenopausal osteoporosis, driven by estrogenic deficiency, induces RANKL and decreases OPG, causing increased resorption with selective horizontal trabecular loss and vertical trabecular thickening [44]. This evidence concerns the gene TNFSF11 and postmenopausal osteoporosis.