Some studies suggest that a lower n-6:n-3 ratio may improve metabolic parameters in adolescents with obesity and fatty liver disease [13], enhance glucose and lipid metabolism in T2DM [14], and decrease serum levels of TNF-α, IL-1β, IL-6, and MCP-1 [15]. The gene discussed is IL1B; the disease is obesity due to melanocortin 4 receptor deficiency.