AFP and hepatocellular carcinoma: Furthermore, our earlier clinical trial of adult patients with hepatocellular carcinoma showed that the addition of Biobran to interventional therapies, including transarterial chemoembolization, percutaneous ethanol injection, radiofrequency ablation, and cryoablation, resulted in improved overall survival, reduced tumor size, less recurrence of cancer, and a lower alpha-fetoprotein level [25].