Nevertheless, because the genotype-specific beneficial effects of HF supplementation on skin phenotypes were significant, we speculate that carriers with the major alleles of rs7705526 and rs2853669 might have upregulation of TERT expression via HF supplementation, leading to increased TERT, which is known to play a role in the antioxidant defense mechanisms besides its role in TL extension [25] in the epidermis. The gene discussed is TERT; the disease is hydrops fetalis.