APP and early-onset autosomal dominant Alzheimer disease: Furthermore, the unsaturated MAOS has been uncovered to play an important role in improving Alzheimer’s disease, which depended on suppressing the aggregation and expression of amyloid-β (Aβ)1–42 oligomer, downregulating the content of amyloid precursor protein (APP) and BACE1, and promoting the fusion of autophagosomes and lysosomes via activating the mTOR signaling pathway [46].