Another VDES mechanism that contributes to reducing the severity of COVID-19 is the powerful negative regulation of the RAAS, by inhibiting the angiotensin-converting enzyme 1 (ACE1)/angiotensin II/AT1R cascade and inducing the ACE2-enhancing effect of angiotensin (1–7) on its receptor (MasR). This evidence concerns the gene MAS1L and COVID-19.