Saini V et al. found a mean ADA of 31.107 ± 29.32 in TB patients with positive sputum and a much higher one (39.478 ± 32.22) among sputum negative TB patients [39], and Salmanzadeh S. et al. found a lower significant serum ADA (24 IU/L) for PTB, with 35% sensibility and 91% specificity [40]. The gene discussed is ADA; the disease is tuberculosis.