Among the identified protective and risk alleles, only DRB1*07:13 (protective; r = 0.2, n = 115, p < 0.05) and DQB1*0201:0301 (risk; r = 0.2, n = 115, p < 0.05) were significantly associated with the viral load at the onset of HIV infection. Here, HLA-DRB1 is linked to HIV infectious disease.