In the HLA-DRB1 locus, the alleles HLA-DRB1*07:13, DRB1*01:13, and DRB1*04:11 were observed less frequently in the research group than in the control group, suggesting their potential protective effect in the case of HIV infection with respect to HIV-associated skin disorders. This evidence concerns the gene HLA-DRB1 and HIV infectious disease.