MPO and eosinophilic granulomatosis with polyangiitis: This study demonstrated that patients with MPO-ANCA-positive EGPA fulfilling the 2022 ACR/EULAR classification criteria exhibited a greater disease burden and poorer health-related quality of life than patients with MPO-ANCA-negative EGPA, as reflected by a higher FFS, elevated markers of systemic inflammation, and lower SF-36 PCS scores.