ERBB2 and neoplasm: In the context of the latest two major updates of the Her2 guidelines, which require that the final ISH results for groups 2–4 be based on a concurrent review of IHC, and the evolving clinical requirements for further Her2 testing stratification, we considered investigating a testing method that combines immunofluorescence assays and FISH (fluorescent in situ hybridization), called the FICTION technique (fluorescence immunophenotyping and interphase cytogenetics as a tool for the investigation of neoplasms).