Interestingly, in a murine model of sepsis, Struck et al. studied the effects of various anti-ADM antibodies directed at different epitopes of ADM and concluded that the best survival benefit was conferred by a certain type of anti-ADM antibody which targeted the N-terminal region of the ADM peptide, but at the same time exhibited weak antagonist activity with only partial inhibition of ADM signaling [36]. Here, ADM is linked to Sepsis.