For the purpose of this narrative review, we searched for relevant peer-reviewed journal articles, written in English, via PubMed (MEDLINE) and Scopus databases using a combination of keywords, such as “bio-adrenomedullin”, “bio-ADM”, “adrenomedullin”, “ADM”, “dipeptidyl peptidase 3”, “DPP3”, “sepsis”, “septic shock”, “biomarkers”. The gene discussed is DPP3; the disease is Sepsis.