Additionally, NSC768313 induces G2/M cell cycle arrest and membrane blebbing in breast cancer cells, such as MDA-MB-231, through tubulin dysregulation, without causing DNA damage, and synergizes with taxanes like paclitaxel by enhancing cytotoxicity via dual targeting of PI-PLC-mediated signaling and microtubule stability. Here, PLCB1 is linked to breast carcinoma.