The PIK3R3-HNF4α-PPARα signaling axis has an important role in lipid metabolism in hepatocytes, and the activation of PIK3R3 reduces hepatosteatosis; thus, PIK3R3 can be regarded as a promising novel target for NAFLD and metabolic syndrome treatment [77]. The gene discussed is HNF4A; the disease is metabolic dysfunction-associated steatotic liver disease.