In addition, it inhibits metastasis by downregulating the metalloproteinases MMP-2 and MMP-9, essential in the degradation of the extracellular matrix, and by disrupting the CXCL12/CXCR4 chemokine axis involved in the epithelial–mesenchymal transition and tumor cell migration [12,25]. Here, MMP9 is linked to neoplasm.