Research could explore questions such as “Are there transcription factors during spermatogenesis that drive PLCZ1 expression?”, “Do hormonal levels (testosterone, FSH) influence the amount of PLCζ a developing spermatid accumulates?”, and “Are there conditions (e.g., high fever, toxins, varicocele) that specifically impact PLCζ production or retention in sperm?”. Here, BRD2 is linked to varicocele.