In total, 29 patients had HER2 MUT (Ex20) NSCLC; of these, 27 patients had PD-L1 score (57% with negative score, 53% with 1–49% and 0% ≥ 50%), and 14 (51.9%) patients were never-smokers. The gene discussed is CD274; the disease is non-small cell lung carcinoma.