AKT1 and Familial prostate cancer: Incaspitolide A, a germacrane-type sesquiterpene lactone isolated from C. cernuum, induced apoptosis in BPH-1 (benign prostatic hyperplasia) cells and PC-3 (prostate cancer) cells via the PI3K/Akt (phosphatidylinositol 3-kinase/protein kinase B) pathway [13,14].