In another study, Varian et al. (2016)’s oral administration of Lactobacillus reuteri in mice with colon cancer cachexia increased gastrocnemius muscle mass and fiber size, lowered plasma TNF-α levels, and upregulated transcription factor FoxN1 (Forkhead Box N1) [58]. Here, FOXN1 is linked to malignant colon neoplasm.