IL10 and cutaneous leishmaniasis: In this sense, ACMD-03 increased IL-10 expression, as this cytokine is responsible for inhibiting the function of M1 macrophages and Th1 lymphocytes, once more emphasizing a possible pro-leishmanial effect of this spiro-acridine in strains of L. amazonensis, but which may be relevant in the regulation of tissue remodeling and wound healing in cutaneous leishmaniasis [61,62].