This finding contrasts interestingly with the regulatory mechanisms of other members of the TRIM family: e.g., TRIM59 deficiency promotes M1 polarization through the STAT1 pathway [49], TRIM24 deficiency enhances M2 polarization and impairs antitumor immunity [50], and Trim33 deficiency affects macrophage dynamics in colitis [51]. Here, TRIM24 is linked to colitis.