Compared with those from clusters III and IV, strains Z7590 and E7885 from cluster I presented significantly greater bacterial loads in the lungs and bloodstream and induced elevated levels of IL-6, TNF-α, and IFN-γ in the lungs and blood of infected mice, which, in turn, leads to the development of inflammatory diseases, such as fever and septic shock [56]. This evidence concerns the gene IL6 and septic shock.