Moreover, HDACs are involved in the regulation of signalling pathways, such as the PI3K/AKT and MEK/ERK signalling pathways, cancer cell metabolism and epithelial–mesenchymal transition (EMT), and all of these processes are relevant and interdependent in the context of drug resistance in cancer [59, 71, 74, 75, 76, 77, 78, 79]. Here, AKT1 is linked to cancer.