To challenge this hypothesis, we injected 2-day old Zebrafish embryos with 2 primary AML PDX samples with FLT3/DNMT3A mutations (FHIT low expression) and 2 primary AML PDX samples with WT FLT3/DNMT3A (FHIT high expression) to serve as controls (Supplementary Fig. 1I). This evidence concerns the gene DNMT3A and acute myeloid leukemia.