FLT3 and acute myeloid leukemia: To challenge this hypothesis, we injected 2-day old Zebrafish embryos with 2 primary AML PDX samples with FLT3/DNMT3A mutations (FHIT low expression) and 2 primary AML PDX samples with WT FLT3/DNMT3A (FHIT high expression) to serve as controls (Supplementary Fig. 1I).