KARS1 and neurodegenerative disease: Typified by the induction of a large panel of lysosome/proteolysis-related genes (for example, cpr-5) and regulated by the GATA transcription factor ELT-2, LySR activation improves proteostasis, reduces protein aggregates and extends healthspan, as well as lifespan in several C. elegans models of neurodegenerative diseases and of normal ageing.