Membership scoring showed that Mitf-high “melanocytic”, “melanocyte”, “Interferon/p53”, “Myc/mTORC1/OxPhos”, “OxPhos”, and “β-catenin/MITF” signatures identified by others in human biopsies, xenografts, cell cultures, and pigmented mouse melanomas were observed mainly in skin melanocytes, only very weakly detected in principal tumor cells, and essentially absent from LNM cells in our tumors (Fig. 4d, e, Fig. S8G). This evidence concerns the gene TP53 and melanoma.