BRAF and melanoma: Specifically, the principal tumor cells had features resembling the “neural crest-like”, “antigen-presenting”, and “mesenchymal” signatures of human melanomas; the “invasion” signature of human xenografts; the “mesenchymal” and “partial-EMT” signatures of Braf CA/+PtenΔ/Δ mouse tumor cells, the “stem-like” signature of NrasQ61K/+Ink4aΔ/Δ mouse tumor cells; the “EMT” signature of CRISPR-edited in-vitro and in-vivo tumor cells; and the “mesenchymal” signature in melanoma cultures (Fig. 4b, Fig. S8E).