IL6 and autosomal dominant polycystic kidney disease: IL-6 signaling has also been shown to play important roles in the pathogenesis of various kidney disorders, including chronic kidney disease (CKD), diabetic nephropathy (DN), acute kidney injury (AKI), and autosomal dominant polycystic kidney disease (ADPKD) (28, 33, 34, 35, 36, 37).