To explore the molecular mechanism of cyst formation induced by the abnormal activity of IL-6/JAK/STAT3 signaling pathway, we focused on FOSL1, a target gene of the IL-6/JAK/STAT3 signaling pathway (48, 49), whose gene expression was greatly increased in xCEP290 morphant kidney in our RNA-seq analysis. Here, FOSL1 is linked to cyst.