In further adjusting the sensitivity analysis for adulthood body size and AMD PRS, nine biomarkers from seven categories still significantly mediated this association, including albumin, cystatin C, Glucose, HbA1c, cholesterol, LDL, IGF-1, CRP, and RBC distribution width (Table S9 in the Online Supplementary Document). The gene discussed is CST3; the disease is age-related macular degeneration.