Existing evidence indicates that inflammation plays a pivotal role in the progression of disc degeneration.[] Upon the onset of IVDD, nucleus pulposus (NP), annulus fibrosus, and immune cells secrete inflammatory cytokines, including tumor necrosis factor (TNF)‐α, interleukin (IL)‐1 α/β, IL‐6, and IL‐17. This evidence concerns the gene TNF and intervertebral disk degenerative disorder.