We tested whether an absence of LCN2 would lead to accelerated IVDD in LCN2 knockout (LCN2−/−) mice (genotyping validation in Figure S4A, Supporting Information) by characterizing for early disc degeneration using magnetic resonance (MR) imaging, micro‐computed tomography (micro‐CT), and histological evaluation. Here, LCN2 is linked to intervertebral disk degenerative disorder.