LRRK2 and Parkinson disease: Analysis of brain tissue from PD patients with LRRK2-p.G2019S and LRRK2-p.I2020T mutations revealed reduced levels of CI-M6PR, suggesting that impaired sorting of lysosomal proteases at the Golgi may contribute to the impaired lysosomal function that has frequently been associated with LRRK2 PD [59,60].