An interesting open question is whether LRRK2’s effect on autophagosomal degradation and the compensatory up-regulation of secretory autophagy in the soma and primary dendrite [141] are also tied to tau pathology, which has been found to show enhanced retrograde spread along neuroanatomical connections in brains of LRRK2-p.G2019S mice and is more prevalent than aSyn pathology in LRRK2 PD cases [151–153]. This evidence concerns the gene LRRK2 and Parkinson disease.