Specifically, we grouped atrial fibrillation (AF), cerebrovascular disease, heart failure (HF), and valvular disease into cardiovascular disease (CVD) cluster [30]; combined blood pressure-related traits and hypertension into a blood pressure (BP) cluster; assigned lipids traits to a Lipid cluster; classified BMI within an obesity cluster; grouped lung cancer and smoking into a respiratory system cluster [31]; and combined glucose, HbA1c, and insulin with type 2 diabetes (T2D) into a T2D cluster. This evidence concerns the gene INS and obesity due to melanocortin 4 receptor deficiency.