APOB and obesity due to melanocortin 4 receptor deficiency: For example, individuals in the lipids-related subgroup had significantly higher relative differences of lipids traits (e.g., lipoprotein(a), apolipoprotein B, LDL-cholesterol, etc.)compared to the remaining high-risk subjects; individuals in the obesity-related subgroup had significantly higher relative differences of obesity traits (BMI, waist circumference, body fat percentage, etc.)compared to the remaining subjects with high CAD PRS (Fig 4 and Table G in S1 Text).