To determine if the requirement for IRF6 for efficient TPA-mediated lytic EBV reactivation is specific to NOKs, we next examined the effect of IRF6 knock-down on TPA-induced lytic EBV reactivation in an EBV + NPC cell line, NPC43, and an EBV + GC cell line, SNU719. This evidence concerns the gene IRF6 and nasopharyngeal carcinoma.