Of note, our finding that both PKCδ and RIPK4 expression are also required (upstream of IRF6) for lytic EBV reactivation in NOKs suggests that pharmacologic inhibitors of either PKCδ and/or RIPK4 might be useful for preventing lytic EBV infection in epithelial cells. The gene discussed is PRKCD; the disease is Epstein-Barr virus infection.