Nevertheless, as relatively little is currently known about the effects of BLIMP1 and KLF4 expression on normal gastric cell and GC tumor cell differentiation, the ability of IRF6 to induce lytic EBV reactivation in GC tumors may also be mediated via additional (BLIMP1/KLF4-independent) mechanisms. The gene discussed is KLF4; the disease is gastric cancer.