Mucopolysaccharidosis Type II (MPS II) is an X-linked lysosomal storage disease characterized by deficiency in the lysosomal hydrolase iduronate 2-sulfatase (IDS), a critical enzyme in the breakdown of the glycosaminoglycans (GAGs) heparan sulfate and dermatan sulfate [1]. Here, IDS is linked to mucopolysaccharidosis type 2.