ICAM2 and rheumatoid arthritis: Further, as shown in Fig 2E, the fold change of the expression levels between ICAM2 and OSTF1 took values ranging from 0.96 to 1.20 with the median of 1.07 in the normal samples, while in the RA samples the fold change took values ranging from 0.85 to 1.06 with the median of 0.96 (Fig 2F).